Journal :   Asian Journal of Research in Chemistry

Volume No. :   1

Issue No. :  1

Year :  2008

Pages :   15-18

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Stability Indicating RP- HPLC Method for Simultaneous Estimation of Valsartan and Amlodipine in Capsule Formulation.



Address:   SS Chitlange1*, Kiran Bagri1 and DM Sakarkar2.
1Dr. D.Y.Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune- 411018
2S. N. Institute of Pharmacy, Pusad
*Corresponding Author
DOI No:

ABSTRACT:
Present work describes a precise, accurate and reproducible Reverse phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of Amlodipine besylate (AMLB) and Valsartan (VAT) on RP C-18 Column (Kromasil, 250 x 4.6 mm) using acetonitrile: phosphate buffer (0.02M, pH 3.0), (56:44 v/v) as mobile phase at a flow rate of 1.0 ml/min and the detection wavelength was 234 nm. The retention time for AMLB and VAT was found to be 3.07 and 6.20 min, respectively. The method was also applied for the determination of AMLB and VAT in the presence of their degradation products formed under variety of stress conditions. Proposed method was validated for precision, accuracy, linearity range, robustness and ruggedness.
KEYWORDS:
Amlodipine besylate, Valsartan, Reverse phase High Performance Liquid Chromatography, Stability indicating method.
Cite:
SS Chitlange, Kiran Bagri, DM Sakarkar. Stability Indicating RP- HPLC Method for Simultaneous Estimation of Valsartan and Amlodipine in Capsule Formulation. Asian J. Research Chem. 1(1): July-Sept. 2008;Page 15-18.
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