Journal :   Asian Journal of Research in Chemistry

Volume No. :   1

Issue No. :  2

Year :  2008

Pages :   53-58

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives



Address:   KP Bhusari1, ND Amnerkar2*, PB Khedekar1, MK Kale2 and RP Bhole1
1Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441 110, M.S. India
2Kamla Nehru College of Pharmacy, Butibori-441 108, M.S., India
*Corresponding Author
DOI No:

ABSTRACT:
A series of sulphonamide derivatives having benzothiazole nucleus have been synthesized by condensation of 2- aminobenzothiazole with 4-acetamidobenzenesulphonyl chloride derivatives in pyridine-acetic anhydride mixture. The identity of the compounds 4-acetamido-N-(1, 3-benzothiazol-2-yl) benzene sulphonamide and 4-amino-N-(1,3- benzothiazol-2-yl)benzene-sulphonamide has been characterized by elemental analysis and spectral data. All the test compounds have been assayed in vitro for antibacterial activity against B. subtilis and E. coli, antifungal activity against C. albicans and the antimycobacterial activity against H37Rv strain of mycobacterium tuberculosis. The test compounds showed significant antibacterial, antifungal and antimycobacterial activity against the microbial strains used.
KEYWORDS:
Benzothiazole, Sulphonamide, Antimicrobial activity.
Cite:
KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole. Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives. Asian J. Research Chem. 1(2): Oct.-Dec. 2008; Page 53-58.
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