Journal :   Asian Journal of Research in Chemistry

Volume No. :   1

Issue No. :  2

Year :  2008

Pages :   74-76

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Absorption Correction Method for Estimation of Nebivolol and Hydrochlorothiazide in Combined Tablet Dosage Form



Address:   PS Tarte*, SP Wate, PB Khedikar and G Pawnikar
Sharad Pawar College of Pharmacy, Wanadongari, Hingana Road, Nagpur-441110 (M.S.)
*Corresponding Author
DOI No:

ABSTRACT:
A new, simple, accurate and sensitive UV-spectrophotometric absorption correction method has been developed for simultaneous determination of Nebivolol and Hydrochlorothiazide in combined pharmaceutical dosage form. The method is based upon determination of Nebivolol at 281 nm and Hydrochlorothiazide at 316.5 nm, in aqueous methanol (20 % v/v). . Nebivolol hydrochloride and Hydrochlorothiazide at their respective ?max 281.0 nm and 316.5 nm shows linearity in the concentration range of 5-35 µg/ml and 10-70 µg/ml respectively. The method was validated statistically.
KEYWORDS:
Nebivolol, Hydrochlorothiazide, absorption correction method, standard addition.
Cite:
PS Tarte, SP Wate, PB Khedikar, G Pawnikar. Absorption Correction Method for Estimation of Nebivolol and Hydrochlorothiazide in Combined Tablet Dosage Form. Asian J. Research Chem. 1(2): Oct.-Dec. 2008; Page 74-76.
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