Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   43-45

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous RP-HPLC Estimation of Nitazoxanide and Ofloxacin in Tablet Dosage Forms



Address:   R Siva Kumar*, P Kumar Nallasivan, S Saravanakumar, CS Kandasamy and R Venkatnarayanan
Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore- 641 402. Tamilnadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
Reverse Phase HPLC method for the determination of nitazoxanide and ofloxacin in bulk and tablet formulations. The determination was carried out by using Phenomenex C18 column with 0.24% sodium lauryl sulphate: acetonitrile: acetic acid (pH-4.0) (58:40:02) as the mobile phase. The flow rate was 1.5 ml/ min. and the eluent was monitored at 295 nm. The Retention time of nitazoxanide and ofloxacin were 2.2 and 5.4 respectively. Linearity for the nitazoxanide and ofloxacin were found in the range of 400-600 µ g/ml and 160 - 240 µ g/ml respectively. The method was reproducible, with good resolution between nitazoxanide and ofloxacin and can be use for routine analysis.
KEYWORDS:
RP-HPLC, Nitazoxanide and Ofloxacin.
Cite:
R Siva Kumar, P Kumar Nallasivan, S Saravanakumar, CS Kandasamy, R Venkatnarayanan. Simultaneous RP-HPLC Estimation of Nitazoxanide and Ofloxacin in Tablet Dosage Forms. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 43-45.
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