Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   70-72

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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RP-HPLC Method for Simultaneous Estimation of Paracetamol and Ibuprofen in Tablets

Address:   Prasanna Reddy Battu1* and MS Reddy2
1Dept. Quality Control and Analytical R and D, Smilax Laboratories Limited, Jeedimetla, Hyderabad-500055, A.P, India.
2Department of Entomology and Plant Pathology, Auburn University, USA
*Corresponding Author

A simple, selective, accurate high Performance Liquid Chromatographic (HPLC) method was developed and validated for the analysis of Paracetamol and Ibuprofen. Chromatographic separation achieved isocratically on a C18 column [Use Inertsil C18, 5ยต , 150 mm x 4.6 mm] utilizing a mobile phase of acetonitrile/phosphate buffer (60:40, v/v, pH 7.0) at a flow rate of 0.8 ml/min with UV detection at 260nm.Aceclofenac was used as an internal standard. The retention time of ibuprofen, paracetamol and aceclofenac was 2.48, 4.45 and 6.34 min respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation.This study aimed at developing and validating an HPLC method, being simple, accurate and selective, and the proposed method can be used for the estimation of these drugs in combined dosage forms.
Paracetamol, Ibuprofen, RP-HPLC, Validation.
Prasanna Reddy Battu, MS Reddy. RP-HPLC Method for Simultaneous Estimation of Paracetamol and Ibuprofen in Tablets. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 70-72.
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