Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   86-89

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form



Address:   Godse VP.* Deodhar MN, Bhosale AV, Sonawane RA, Sakpal PS, Borkar DD and Bafana YS
Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy,Saswad, Pune- 412 301, India
* Corresponding Author
DOI No:

ABSTRACT:
Two simple, sensitive accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Atorvastatin in two components solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 232.5 nm and Atorvastatin has Absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 mcg/ml for both Ezetimibe and Atorvastatin.In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at iso- absorptive point and at max of one of the drug. The results of analysis have been validated statistically and by recovery studies.
KEYWORDS:
Ezetimibe, Atorvastatin, Simultaneous Equations, Absorbance Ratio, Iso-absorptive Point.
Cite:
Godse VP., Deodhar MN, Bhosale AV, Sonawane RA, Sakpal PS, Borkar DD, Bafana YS. Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin inPharmaceutical Dosage Form. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 86-89.
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