Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   37-40

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Reverse Phase HPLC Method for Determination of Aceclofenac and Paracetamol in Tablet Dosage Form



Address:   Godse VP.* Deodhar MN, Bhosale AV, Sonawane RA, Sakpal PS, Borkar DD and Bafana YS
Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy,Saswad, Pune- 412 301, India
* Corresponding Author
DOI No:

ABSTRACT:
A simple, rapid and selective HPLC method has been developed for quantitation of aceclofenac and paracetamol from bulk drug and pharmaceutical formulations using a mobile phase consisting mixture of methanol and water (70:30 v/v) at the flow rate of 1mL/min. An ODS C-18 (Intersile 25 cm x 4.6 mm, 10 µ m.) column was used as stationary phase. The retention time of aceclofenac and paracetamol were 1.8 min. and 2.7 min. respectively. Linearity was observed in the concentration range of 2-50 µ g/mL for aceclofenac and 5-50 µ g/mL for paracetamol. Percent recoveries obtained for aceclofenac and paracetamol were 100.6 and 100.7 respectively. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of aceclofenac and paracetamol.
KEYWORDS:
Aceclofenac, Paracetamol, HPLC Method.
Cite:
Godse VP., Deodhar MN, Bhosale AV, Sonawane RA, Sakpal PS, Borkar DD, Bafana YS. Reverse Phase HPLC Method for Determination of Aceclofenac and Paracetamol in Tablet Dosage Form. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 37-40.
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