Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   139-142

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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RP- HPLC Method for Simultaneous Estimation of Pseudoephidrine Sulphate and Desloratidine from Bulk and Tablets



Address:   RK Godge*, MC Damle, SR Pattan, PN Kendre, S N Lateef and PJ Burange
Pravara Rural college of Pharmacy, Pravaranagar, Dist. Ahemadnagar 413 736. (MS) India
*Corresponding Author
DOI No:

ABSTRACT:
A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed for the simultaneous estimation of Pseudoephidrine sulphate and Desloratidine from pharmaceutical formulation by using internal standard Nabumetone. The method was carried out on a HiQ sil C18 W (250mm x 4.6 mm) column, with a mobile phase consisting of Acetonitrile: Methanol :Ammonium acetate (45:40:15 v/v) at a flow rate of 1.5 ml/min. Detection was carried out at 265 nm. The retention time of Pseudoephidrine sulphate, Desloratidine, and Nabumetone were 2.067, 3.050 and 3.750min. Respectively. The developed method was validated in terms of accuracy, precision, linearity, Limit of detection, Limit of quantitation. The proposed method can be used for estimation of these drugs in combined dosage form for routine analysis.
KEYWORDS:
Pseudoephidrine sulphate, Desloratidine, Nabumetone, RP-HPLC.
Cite:
RK Godge, MC Damle, SR Pattan, PN Kendre, S N Lateef, PJ Burange. RP- HPLC Method for Simultaneous Estimation of Pseudoephidrine Sulphate and Desloratidine from Bulk and Tablets. Asian J. Research Chem. 2(2): April.-June, 2009 page 139-142.
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