Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   154-156

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Statistical Validation of Spectrophotometric Method for Estimation of Esomeprazole in Tablet Dosage Form



Address:   Patil Shamkant S*1, Dhabale Pandurang N1 and Kuchekar Bhanudas S2
1Govt. College of Pharmacy, Vidyanagar, Karad-415124, Maharashtra, India
2Maharashtra Institute of Pharmacy, Pune, Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Three simple, precise and economical UV methods have been developed for the estimation of Esomeprazole in bulk and pharmaceutical formulations. Esomeprazole has the absorbance maxima at 303nm (Method A), and in the first order derivative spectra, showed zero crossing at 303nm, with a sharp peak at 292nm when n=1 (Method B), Method C applied was Area Under Curve (AUC) for analysis of Esomeprazole in the wavelength range of 294-310nm. Drug followed the Beer’s Lamberts range of 5-40 µg/ml for the Method A, B C. Results of analysis were validated statistically and by recovery studies and were found to be satisfactory.
KEYWORDS:
Esomeprazole, UV Spectrophotometry, Derivative Spectroscopy, Area Under Curve.
Cite:
Patil Shamkant S, Dhabale Pandurang N, Kuchekar Bhanudas S. Development and Statistical Validation of Spectrophotometric Method for Estimation of Esomeprazole in Tablet Dosage Form. Asian J. Research Chem. 2(2): April.-June, 2009 page 154-156
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