Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   157-161

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones



Address:   Firke SD*1, Firake BM1, Chaudhari RY2 and Patil VR2
1KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India
2TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India
*Corresponding Author
DOI No:

ABSTRACT:
A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation.
KEYWORDS:
Thiazolidinone, Pyridine, Antidiabetic activity.
Cite:
Firke SD, Firake BM, Chaudhari RY, Patil VR. Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones. Asian J. Research Chem. 2(2): April.-June, 2009 page 157-161.
[View HTML]      [View PDF]



Visitor's No. :   120993