Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   157-161

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones

Address:   Firke SD*1, Firake BM1, Chaudhari RY2 and Patil VR2
1KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India
2TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India
*Corresponding Author

A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation.
Thiazolidinone, Pyridine, Antidiabetic activity.
Firke SD, Firake BM, Chaudhari RY, Patil VR. Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones. Asian J. Research Chem. 2(2): April.-June, 2009 page 157-161.
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