Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   222-224

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Method of Cefuroxime Axetil in Bulk and Pharmaceutical Formulation



Address:   Santosh Shelke*1, Santosh Dongre1, Amit Rathi2, Dinesh Dhamecha2, Saifee Maria2 and Mohd Hassan G Dehghan 2
1 Yash Institute of Pharmacy, South city, Bajaj Nagar, Post Box no. 968,Waluj,Aurangabad-431134
2 Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg,Aurangabad-431001
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of cefuroxime axetil in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 281nm.The percentage recovery of cefuroxime axetil ranged from (99.97 ± 0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 4-28µg/ml having line equation y = 0.0346x + 0.0566 with correlation coefficient of 0.9999. Results of the analysis were validated statistically and by recovery study.
KEYWORDS:
UV spectrophotometry, cefuroxime axetil.
Cite:
Santosh Shelke, Santosh Dongre, Amit Rathi, Dinesh Dhamecha, Saifee Maria, Mohd Hassan G Dehghan. Development and Validation of UV Spectrophotometric Method of Cefuroxime Axetil in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 2(2): April.-June, 2009 page 222-224.
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