Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   112-114

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Method for Simultaneous Estimation of Paracetamol and Domperidone in Tablet Formulation



Address:   Kalra Kapil*, Naik S, Jarmal Garima and Mishra N
Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, Orissa
*Corresponding Author
DOI No:

ABSTRACT:
The development of Vireodt's method for simultaneous estimation of paracetamol and domperidone involves absorbance measurement at 250 nm and 285 nm corresponding to the respective absorption maxima. Both the drugs obey Beer Lambert's law in the range of 5-30 µg/ml for paracetamol and 0.8-5 µg/ml for domperidone. The tablet formulation (Grenil, KAPL) was evaluated for the percent content of both the drugs at the selected wavelengths. The method developed was validated to determine its accuracy, precision, specificity and ruggedness. The recovery study was carried out by standard addition method. The average percent recovery was found to be 99.45±0.47 for paracetamol and 100.67±0.18 for domperidone.
KEYWORDS:
Paracetamol, Domperidone, Spectrophotometric estimation.
Cite:
Kalra Kapil, Naik S, Jarmal Garima, Mishra N. Spectrophotometric Method for Simultaneous Estimation of Paracetamol and Domperidone in Tablet Formulation. Asian J. Research Chem. 2(2): April.-June, 2009 page 112-114.
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