Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   123-126

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities



Address:   Pattan Shashikant R*1, Kekare Prajact2, NS Dighe1, SB Bhawar4, Nikalje Ana3, Pati Ashwini3 and MB Hole1
1Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar
2Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy,Belgaum 590 010
3Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad
4Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar
*Corresponding Author
DOI No:

ABSTRACT:
A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All the compounds (B1-B9) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.
KEYWORDS:
Thiazolidinedione, antidiabetic activity, microwave assisted synthesis.
Cite:
Pattan Shashikant R, Kekare Prajact, NS Dighe, SB Bhawar, Nikalje Ana, Pati Ashwini, MB Hole. Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities. Asian J. Research Chem. 2(2): April.-June, 2009, Page 123-126.
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