Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   270-272

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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New Spectrophotometric Methods for the Estimation of Cefditoren Pivoxil



Address:   S Appala Raju*, Arvind B Karadi and Shobha Manjunath
HKE’s College of Pharmacy, Gulbarga-585 105 (KS) India
*Corresponding Author
DOI No:

ABSTRACT:
Two simple and sensitive spectrophotometric methods (A and B) for the quantitative estimation of cefditoren pivoxil in bulk drug and pharmaceutical preparations. These methods are based on diazotization of cefditoren with nitrous acid followed by coupling in situ with phloroglucinol (method-A), Resorcinol (method-B) to yield orange yellow colored chromogen and exhibits absorption maximum at 462 and 455 nm respectively. Colored chromogens are stable for 4-6 hrs. and obeyed Beer’s law in the concentration range of 20-80 ?g/ml. and 10-50 ?g/ml. for (method-A and B) respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The results are comparing with those obtained using UV spectrophotometric method in 0.1 N HCl at 233 nm.
KEYWORDS:
Cefditoren, resocinol, phloroglucinol, spectrophotometry.
Cite:
S Appala Raju, Arvind B Karadi, Shobha Manjunath. New Spectrophotometric Methods for the Estimation of Cefditoren Pivoxil. Asian J. Research Chem. 2(3): July-Sept. 2009 page 270-272.
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