Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   278-279

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Selective Visible Spectrophotometric Estimation of Ambroxol Hydrochloride in Presence of Cetirizine Hydrochloride in Tablets



Address:   Potdar VH1*, Kuchekar BS2 and Patil SS1
1Tatyasaheb Kore College of Pharmacy, Warananagar-416113, Maharashtra, India
2 MAEER’S Maharashtra Institute of Pharmacy, Kothrud, Pune, Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
The objective of this work was to develop a simple, accurate, rapid and sensitive method for the estimation of ambroxol hydrochloride in presence of cetirizine hydrochloride in tablets. The estimation is based on the reduction of ferric from ferric nitrate to ferrous ions by the drug (ambroxol hydrochloride),which further in presence of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride (MBTH), to produce red colored complex, measured at 568 nm. The chromogen obeyed linearity over 6-54 ?g/ml (r=0.9988) with percent relative standard deviation (% RSD) of 0.16, showing that method has good accuracy and precision.
KEYWORDS:
Ambroxol hydrochloride, Cetirizine hydrochloride, MBTH, Ferric nitrate.
Cite:
Potdar VH, Kuchekar BS, Patil SS. Selective Visible Spectrophotometric Estimation of Ambroxol Hydrochloride in Presence of Cetirizine Hydrochloride in Tablets. Asian J. Research Chem. 2(3): July-Sept. 2009 page 278-279.
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