Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   289-291

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases



Address:   RA Hajare*1, RM Gaurkhede1, PP Chinchole1, AV Chandewar1, AS Wandhare1 and SS Karki2
*P.W. College of Pharmacy, Dhamangaon Road, Yavatmal. 445001 (M.S.)
1K.L.E. College of Pharmacy, Rajaji Nagar, Bangalore - 560010
*Corresponding Author
DOI No:

ABSTRACT:
Isatin (1H-indole-2, 3-Dione) is synthetically versatile molecule. Erdman and Laurent first obtained it in 1841 as a product from the oxidation of indigo by nitric acid and chromic acid. Isatin (Indole 2’3 dione), its 5-halo derivatives were reacted to form the Schiff’s bases,Mannich bases and Friedal Craft Alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies it reveals that the isatin were undergoes reaction at C-3 and N-1 position. The structures of the synthesized derivatives were characterized from 1 H-NMR, IR spectral data and elemental analysis. The most of the compound synthesized were shown to possess biological activity.
KEYWORDS:
Isatin, Schiff’s Base, N-Benzylation, Dimethyl formamide.
Cite:
RA Hajare, RM Gaurkhede, PP Chinchole, AV Chandewar, AS Wandhare, SS Karki. Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases. Asian J. Research Chem. 2(3): July-Sept., 2009, page 289-291.
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