Journal : Asian Journal of Research in Chemistry
Volume No. : 2
Issue No. : 3
Year : 2009
Pages : 300-303
ISSN Print : 0974-4169
ISSN Online : 0974-4150
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Swapna S Kulkarni1, AP Mehere2 and Priyank A Shenoy1*
1Alard College of Pharmacy, Sr.no 50, Marunje, Rajiv Gandhi Infotech Park, Pune-411057, Maharashtra, India
Sharad Pawar College of Pharmacy, Wanadongari, Nagpur, Maharashtra, India
*Corresponding Author
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DOI No:
ABSTRACT:
An amide derivative of P-aminobenzoic acid (PABA) has been synthesized from piperazine by initial conversion of PABA into its hydrochloride salt for protection of amino group from self-polymerization. The compound identity has been characterized by Melting point, Elemental Analysis, TLC, UV-Visible spectroscopy, IR spectroscopy and NMR spectroscopy. The antibacterial activity of the compound has been studied against E.coli, S.aureus, B.subtilis and P.aeruginosa using tetracycline as a standard. Antifungal activity of the compound has been studied against C.albicans and A.niger using clotrimazole as a standard. The synthesized compound has been found to possess significant antibacterial and antifungal activities as compared to the standard drugs used.
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KEYWORDS:
Amide derivative, PABA, Self-Polymerization, Antibacterial, Antifungal.
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Cite:
Swapna S Kulkarni, AP Mehere, Priyank A Shenoy. Synthesis and In-Vitro Antimicrobial Activity of 4-(Piperazin-1-Ylcarbonyl) Aniline – An Amide Derivative of P-Aminobenzoic Acid. Asian J. Research Chem. 2(3): July-Sept., 2009, page 300-303.
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