Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   310-313

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Some New Substituted 1, 4-Dihydropyridine Derivatives and Their Anti-inflammatory Activity



Address:   SR Pattan*1, NS Dighe1, SV Hiremath2, AN Merekar3, VM Gaware1, DS Musmade1 and PM Gaikwad4
1Dept of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni 413713, India
2Dept of Pharmacology J.N Medical College Belgaum, India
3Dept of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Loni 413713, India
4Dept of Pharmacology, Pd. Dr. Vitthalrao Vikhe Patil College of Pharmacy, Ahmednagar, India
*Corresponding Author
DOI No:

ABSTRACT:
A new series if substituted 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by paw edema, xylene induced ear edema and cotton wool granuloma methods. Compounds C4, C5, C6, C7 and C9 have been found to exhibit excellent anti-inflammatory activity.
KEYWORDS:
1, 4-Dihydropyridine, anti-inflammatory, CHN analysis.
Cite:
SR Pattan, NS Dighe, SV Hiremath, AN Merekar, VM Gaware, DS Musmade, PM Gaikwad. Synthesis and Evaluation of Some New Substituted 1, 4-Dihydropyridine Derivatives and Their Anti-inflammatory Activity. Asian J. Research Chem. 2(3): July-Sept., 2009, page 310-313.
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