Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   246-249

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole



Address:   Bele DS1* and Singhvi I2
1B N Girls College of Pharmacy, Udaipur (Raj.)
2Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur (Raj.)
*Corresponding Author
DOI No:

ABSTRACT:
Nine new mannich bases were synthesized by reaction between 6-substituted-2-amino-benzothiazole and 5-substituted-1-(1H-1,2,4-triazol-1-yl)-ethanone in presence of formaldehyde and conc. HCl. The synthesized compounds were characterized by IR and 1H-NMR spectroscopy. All the synthesized compounds were screened for in vitro antimicrobial activity against the pathogens S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Few synthesized derivatives were found to exhibit good antimicrobial activity.
KEYWORDS:
2-aminobenzothiazole, mannich base, 1H-1,2,4-triazole, antimicrobial.
Cite:
Bele DS, Singhvi I. Synthesis and Antimicrobial Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole. Asian J. Research Chem. 2(3): July-Sept. 2009 page 246-249.
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