Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   258-259

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Atomoxetine Hydrochloride from Its Pharmaceutical Dosage Forms



Address:   Koradia SK*, Shah PT, Rana RR, Vaghani SS, Pandey S and Jivani NP
Smt. Rupaben B. Patel Mahila Pharmacy College, Atkot-360 040 Gujarat, INDIA
*Corresponding Author
DOI No:

ABSTRACT:
A simple, economic and reproducible spectrophotometric method has been developed for the determination of HCl in bulk and in its pharmaceutical formulations. The spectrophotometric method was carried out at maximum absorbance of 270.0 nm for Atomoxetine HCl using double distilled water (DDW) as a solvent. The linearity over the concentration range of Atomoxetine HCl was found to be 20-180 µg/ml with correlation coefficient 0.9997. The detection limit and quantitation limit were found to be 4.04 µg/ml and 12.25 µg/ml, respectively. Results of analysis were validated statistically and by recovery studies. Commercial capsule formulations were successfully analyzed using the developed method.
KEYWORDS:
Atomoxetine HCl, Spectrophotometry, Capsules, Method validation.
Cite:
Koradia SK, Shah PT, Rana RR, Vaghani SS, Pandey S, Jivani NP. Spectrophotometric Determination of Atomoxetine Hydrochloride from Its Pharmaceutical Dosage Forms. Asian J. Research Chem. 2(3): July-Sept., 2009, page 258-259.
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