Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   407-410

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Facile and Efficient Oxidation of Sulfides to Sulfoxides Using Oxone® and its Biological Evaluation



Address:   NS Mahajan1*, RL Jadhav1, KK Mali1, NV Pimpodkar1 and AM Manikrao2
1Department of Pharmaceutical Chemistry, Satara College of Pharmacy, Plot No. 1539, New Add MIDC, Degaon, Satara, Maharashtra 415 004
2Parul College of Pharmacy, Vadodara, Gujarat
*Corresponding Author
DOI No:

ABSTRACT:
A “green” highly sensitive oxidation of organic sulfides, N-substituted-ß- (4-phenyl-2-thiazolyl) thio-alkyl/aryl acetamides (I) to the corresponding sulfoxides (II) was developed employing solid-state condition by using Oxone®. The synthesized compounds were confirmed by using elemental analysis and spectral data. These synthesized compounds were tested for their antibacterial and antifungal activities. None of them were found to possess any promising activity. This oxidation system is found clean, safe and operationally simple, environmental friendly and for these reasons meets the needs of contemporary “green chemistry” and is suitable for practical synthesis.
KEYWORDS:
Antibacterial activity, antifungal activity, Oxone®, oxidation.
Cite:
NS Mahajan, RL Jadhav, KK Mali, NV Pimpodkar, AM Manikrao. Facile and Efficient Oxidation of Sulfides to Sulfoxides Using Oxone® and its Biological Evaluation. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 407-410.
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