Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   437-439

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anti-Bacterial Study of 6, 8- Disubstituted -3-(4-(4- Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine



Address:   Kiran J Suthar *, Harsha U Patel, Chhaganbhai N Patel and Vimal Patel
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
6, 8- Disubstituted -3-(4-(4- Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo[E][1,3]Oxazine have been prepared from 2-amino 4-substituted Phenyl thiazole react with substituted salicyladehyde results in 2,4- disubstituted -6-((4-(4- substituted phenyl)thiazol-2-ylimino)methyl)phenol. Then reacted with NaBH4, it give 2,4-disubstituted -6-((4-(4- substituted phenyl)thiazol-2-ylamino)methyl)phenol. Which is reacted with fomalin in chloroform yields 6, 8- Disubstituted -3-(4-(4- Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo[E][1,3]Oxazine.All the title compounds characterised on the basis of their MASS, 1H NMR spectroscopic data analysis.
KEYWORDS:
Synthesis, Thiazole, salicyladehyde, Anti-Bacterial activity.
Cite:
Kiran J Suthar, Harsha U Patel, Chhaganbhai N Patel, Vimal Patel. Synthesis and Anti-Bacterial Study of 6, 8- Disubstituted -3-(4-(4- Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 437-439.
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