Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   440-444

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives



Address:   *Raga Basawaraj and Majid Shabbir
Post-Graduate Centre, Dept.of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403
*Corresponding Author
DOI No:

ABSTRACT:
2-Arylamino/arylidinehydrazino-4-(4-methoxyphenyl-2-yl) thiazoles were obtained by the reaction of 1-bromoacetyl-4-methoxyphenyl with various substituted arylthioureas and arylidinethiosemicarbazides in ethanol. Aminogroup of aryl thiazole have been treated with different aromatic aldehydes afford corresponding schiff bases, which on further treated with chloroacetylchloride and mercaptoacetic acid converted to corresponding azetidinones and thiazolidinones. All the compounds were characterized on basis of analytical and spectral data and these compounds were screened for invitro antimicrobial activity.
KEYWORDS:
Arylthiazole, Schiff’s bases, Azetidinones, Thiazolidinones, Antimicrobial activity.
Cite:
Raga Basawaraj, Majid Shabbir. Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 440-444.
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