Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   454-456

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Entacapone in Pharmaceutical Preparations by Liquid Chromatography



Address:   P Nagaraju*, D Narendra, P Jitendra Kumar, VDN Srinivas and SVN Padma
Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002
*Corresponding Author
DOI No:

ABSTRACT:
A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the estimation of entacapone in its dosage forms using C18 column. The mobile phase (acetonitrile and 20mM potassium dihydrogen phosphate, PH 3.5) was pumped at a flow rate of 1 ml / min in the ratio of 80:20 and the eluents were monitored at 320 nm. The intra- and inter- day variation was found to be less than 2% showing high precision of the assay method. The mean recovery of the drug from the solution containing 200 or 300 ?g / ml was 99.66 ± 1.20% indicating high accuracy. The proposed HPLC method may be used for determining entacapone in bulk drug samples or in pharmaceutical dosage forms.
KEYWORDS:
Estimation, entacapone, tablets and HPLC.
Cite:
P Nagaraju, D Narendra, P Jitendra Kumar, VDN Srinivas, SVN Padma. Determination of Entacapone in Pharmaceutical Preparations by Liquid Chromatography. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 454-456.
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