Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   461-463

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Abacavir sulfate and Lamivudine in Tablet Dosage Form



Address:   Mirza Shahed*, Palaskar Pallavi S, MHG Dehghan and SN Mokale
Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad-431001
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, accurate, precise, methods were developed for the estimation of Abacavir sulfate and Lamivudine in Tablet dosage form. Both the drugs are used against the HIV infection as reverse transcriptase inhibitors. Method A is Simultaneous equation method, wavelength selected for Quantitation are 284.0 nm and 270.0 nm for Abacavir sulfate (ABAC) and Lamivudine (LAM) respectively which are the ?max of both the drugs. Method B is Q –Analysis method, wavelength selected were 284.0 nm (?max of ABAC) and 265.0 nm (Isobestic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 5-30 mcg/ml for ABAC and LAM respectively. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
KEYWORDS:
Abacavir sulfate, Lamivudine, Simultaneous equation method and Q-Analysis method.
Cite:
Mirza Shahed, Palaskar Pallavi S, MHG Dehghan, SN Mokale. Simultaneous Spectrophotometric Estimation of Abacavir sulfate and Lamivudine in Tablet Dosage Form. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 461-463.
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