Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   467-468

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmacuetical Formulations



Address:   M.Sundarapandian*1, S.Venkataraman2, R.Xavierarulappa2, M.Boopathi1 and S.Selvakumar2
Department of Pharmaceutical Analysis, Department of Pharmaceutical Analysis1, Department of Pharmaceutical Chemistry2 K.M.College of Pharmacy, Uthangudi, Madurai -625 107
*Corresponding Author
DOI No:

ABSTRACT:
A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Meloxicam has been developed based on the formation of ion-pair of Meloxicam with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415nm. Beer’s law limit was found to be 10-50mcg/ml. The molar absorptivity was found to be 2.17x103(mole-1cm-1) and sandell’s sensitivity was 0.1612 (µg/cm2/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.88 and 2.69 mcg/ml respectively of Meloxicam. The result of estimation in marketed formulations was found to be 99.86±0.32 and 97.93±0.32. The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.
KEYWORDS:
Meloxicam, Bromo cresol green, Specrophotometry.
Cite:
M.Sundarapandian, S.Venkataraman, R.Xavierarulappa, M.Boopathi, S.Selvakumar. Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmacuetical Formulations. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 467-468.
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