Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   467-468

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmacuetical Formulations

Address:   M.Sundarapandian*1, S.Venkataraman2, R.Xavierarulappa2, M.Boopathi1 and S.Selvakumar2
Department of Pharmaceutical Analysis, Department of Pharmaceutical Analysis1, Department of Pharmaceutical Chemistry2 K.M.College of Pharmacy, Uthangudi, Madurai -625 107
*Corresponding Author

A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Meloxicam has been developed based on the formation of ion-pair of Meloxicam with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415nm. Beer’s law limit was found to be 10-50mcg/ml. The molar absorptivity was found to be 2.17x103(mole-1cm-1) and sandell’s sensitivity was 0.1612 (µg/cm2/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.88 and 2.69 mcg/ml respectively of Meloxicam. The result of estimation in marketed formulations was found to be 99.86±0.32 and 97.93±0.32. The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.
Meloxicam, Bromo cresol green, Specrophotometry.
M.Sundarapandian, S.Venkataraman, R.Xavierarulappa, M.Boopathi, S.Selvakumar. Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmacuetical Formulations. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 467-468.
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