Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   506-508

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Telmisartan in Solid Dosage Form by RP-HPLC

Address:   NR Vekariya*, GF Patel and Rohit B Dholakiya
Shree Dhanvantary Pharmacy College, Kim – Surat. Gujarat (India)
*Corresponding Author

A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Telmisartan in tablet dosage form. Luna 5 µ C18, 250 × 4.6 mm, particle size 5 µm, with mobile phase consisting of 5 mM Phosphate buffer: Acetonitrile (60:40, v/v), pH 7.4 was used. The flow rate was 1 ml/min and the effluents were monitored at 295 nm. The retention time was 7.02 min. The detector response was linear in the concentration of 2-14 µg/ml. The respective linear regression equation being Y=61480X-10188. The limit of detection and limit of quantification was 0.06 and 0.18 mcg/ml respectively. The percentage assay of Telmisartan was 100.28 ± 0.93 %. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Telmisartan in bulk drug and in its pharmaceutical dosage form.
RP-HPLC, Telmisartan, Validation.
NR Vekariya, GF Patel, Rohit B Dholakiya. Determination of Telmisartan in Solid Dosage Form by RP-HPLC. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 506-508.
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