Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   516-518

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some Benzimidazolyl Pyrazolone Derivatives



Address:   Ameya G Yadav, Vrushali Patil, AS Bobade, SV Athlekar, LS Patil and Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai- 400012
DOI No:

ABSTRACT:
A series of 2-(1H- benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted)phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.
KEYWORDS:
Benzimidazole, Pyrazolone, anti–bacterial, anti–fungal.
Cite:
Ameya G Yadav, Vrushali Patil, AS Bobade, SV Athlekar, LS Patil, Abhay Chowdhary. Synthesis and Antimicrobial Activity of Some Benzimidazolyl Pyrazolone Derivatives. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 516-518.
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