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Asian Journal of Research in Chemistry
ISSN: 0974-4150(Online), 0974-4169(Print)
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Journal :
Asian Journal of Research in Chemistry
Volume No. :
2
Issue No. :
4
Year :
2009
Pages :
523-525
ISSN Print :
0974-4169
ISSN Online :
0974-4150
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Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes
Soram Ibomcha Singh
,
Shashi Prabha
ibomsoram@yahoo.co.uk
Address:
Soram Ibomcha Singh and Shashi Prabha*
School of Studies in Chemistry, Jiwaji University, Gwalior-474011
*Corresponding Author
DOI No:
ABSTRACT:
Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho- or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FT-IR, 31P NMR and GC-MS spectral studies.
KEYWORDS:
Phosphorylation, phosphoramidates, anticholinesterase, 31P NMR, toxicity.
Cite:
Soram Ibomcha Singh, Shashi Prabha. Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 523-525.
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