Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   523-525

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes


Soram Ibomcha Singh, Shashi Prabha

ibomsoram@yahoo.co.uk

Address:   Soram Ibomcha Singh and Shashi Prabha*
School of Studies in Chemistry, Jiwaji University, Gwalior-474011
*Corresponding Author
DOI No:

ABSTRACT:
Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho- or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FT-IR, 31P NMR and GC-MS spectral studies.
KEYWORDS:
Phosphorylation, phosphoramidates, anticholinesterase, 31P NMR, toxicity.
Cite:
Soram Ibomcha Singh, Shashi Prabha. Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 523-525.
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