Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   529-235

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives



Address:   P Muthumani*, R Meera, Pratesh, N Chidambaranathan, P Devi and Bkameswari
K.M. College of Pharmacy, Uthangudi, Madurai – 625 107. TamilNadu, India
*Corresponding Author
DOI No:

ABSTRACT:
A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff’s bases with thiooglycollic acid. The substituted schiff’s bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.
KEYWORDS:
Substituted 4-thiazolidinonnes, Anticonvulsant, Anti hyperglycemic, Anti bacterial.
Cite:
P Muthumani, R Meera, Pratesh, N Chidambaranathan, P Devi, Bkameswari. Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 529-535.
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