Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   547-549

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Method of Ambroxol Hydrochloride in Bulk and Pharmaceutical Formulation



Address:   Chhotaram Seervi*, Kundan Pawar , PN Dhabale, ID Gonjari, Chandrakant Raut and Deepali Gharge
Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, precise and economical UV methods have been developed for the estimation of Ambroxol Hydrochloride in bulk and pharmaceutical formulations. Ambroxol Hydrochloride has the absorbance maxima at 246.5nm (Method A), and in the first order derivative spectra showed sharp peak at 240 nm (Method B). Linearity for detector response was observed in the concentration range of 10-50 µg/ml for all two methods. The proposed methods were successfully applied for the estimation of Ambroxol Hydrochloride in commercial pharmaceutical preparation by using simple solvent Distilled water. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, Limit of Detection and Limit of Quanti?cation and specificity were found to be satisfactory.
KEYWORDS:
Ambroxol Hydrochloride, UV spectrophotometry, Absorbance maxima, Derivative spectroscopy.
Cite:
Chhotaram Seervi, Kundan Pawar , PN Dhabale, ID Gonjari, Chandrakant Raut, Deepali Gharge. Development and Validation of UV Spectrophotometric Method of Ambroxol Hydrochloride in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 547-549.
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