Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   556-560

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity



Address:   Shashikant R Pattan*1, Nachiket S Dighe1, Anand A Bukitagar, Prerana A Chavan1, Snehlata K Tambe1, Deepak S Musmade 1 and S V Hiremath2
1Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S.India
2 Department of Pharmacology, JNMC, Belgaum, Karnataka
*Corresponding Author
DOI No:

ABSTRACT:
A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole- Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C1, C2, C3, C4, C5, D1, D2, D3, D4, D5, E1, E2, E3, and E4 have been found to exhibit excellent anti-convulsant activity.
KEYWORDS:
Phenylthiazole, Anti-convulsant.
Cite:
Shashikant R Pattan, Nachiket S Dighe1, Anand A Bukitagar, Prerana A Chavan, Snehlata K Tambe, Deepak S Musmade, S V Hiremath. Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 556-560.
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