Journal :   Asian Journal of Research in Chemistry

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   561-564

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations



Address:   Y Rajendraprasad1, KK Rajasekhar2*, V Shankarananth2, S Bharath kumar2, G Dileep kumar2 and T Sreelekha2
1Department of Pharmaceutical Chemistry, AU college of Pharmaceutical Sciences, Andhra University, Vishakapatnam-530003,A.P,India
*2.Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor,Tirupati-517503,A.P,India
*Corresponding Author
DOI No:

ABSTRACT:
The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250x4.6 mm,5ยต) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30).The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.
KEYWORDS:
HPLC estimation, Validation, Domperidone and Pharmaceutical formulation.
Cite:
Y Rajendraprasad, KK Rajasekhar, V Shankarananth, S Bharath kumar, G Dileep kumar, T Sreelekha. RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 561-564.
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