Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   47-50

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of Some Novel 2-Aminobenzothiazole Derivatives as Potential Analgesic Agents



Address:   Pankaj Gupta, Hardwari Lal Yadav, G. Garg, R.S. Pawar, U.K. Patil and P.K. Singour*: Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal, M.P, 462044, India
*Corresponding Author
DOI No:

ABSTRACT:
A series of 1-(2/4-substituted-benzoyl)-3-benzothiazol-2-yl-thiourea were synthesized from benzothiazol-2-yl-amine and 2/4-substituted benzoylisothiocyanates in satisfactory yields. The newly synthesized compounds were characterized by UV, IR, and 1H-NMR spectroscopy. The synthesized compounds were evaluated for analgesic activity by hot plate method using aspirin (100mg/kg) as standard compound. The results highlights that the some compound shows significant analgesic activity.
KEYWORDS:
2-Aminobenzothiazole derivatives, Synthesis, Analgesic activity.
Cite:
Pankaj Gupta, Hardwari Lal Yadav, G. Garg, R.S. Pawar, U.K. Patil, P.K. Singour. Synthesis and Biological Evaluation of Some Novel 2-Aminobenzothiazole Derivatives as Potential Analgesic Agents. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 47-50.
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