Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   58-59

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Estimation of Gatifloxacin in Tablet Dosage Form by Spectrofluorimetric Method



Address:   Meeta A Jiladia*1, SS Pandya2 and Ashok G Jiladia3
1Veerayatan Institute of Pharmacy, Jakhania Bhuj-Mandvi Road, Mandvi- 370640
2Babaria Institute of Pharmacy, Vadodara - 391240
3Jiladia Hospital, New Anjar, Anjar (Kutch) - 370110
*Corresponding Author
DOI No:

ABSTRACT:
Three simple and sensitive spectrofluorimetric methods have been developed for the determination of gatifloxacin and its tablet dosage forms. In fluorescence spectrum of gatifloxacin exhibit excitation and emission wavelength at 295 and 498 nm in hydrochloric acid, 295 and 489 nm in acetate buffer pH-4 and 337 and 488 nm, in phthalate buffer pH-4, respectively. The fluorescence intensity for all three methods was found to be linear with the concentration in the range of 200-1000 ng/ml. The % recovery for gatifloxacin was found in the range of 97.0–102.6% in hydrochloric acid, 99.5–100.2% in acetate buffer, 98.3–100.1% in phthalate buffer. These methods were found to be simple, accurate, reproducible and economical and can be used for the routine analysis of gatifloxacin in bulk drug and its tablets.
KEYWORDS:
Gatifloxacin, hydrochloric acid, acetate buffer, phthalate buffer pH-4.
Cite:
Meeta A Jiladia, SS Pandya, Ashok G Jiladia. Estimation of Gatifloxacin in Tablet Dosage Form by Spectrofluorimetric Method.Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 58-59.
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