Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   116-120

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Some Novel Coumarino Benzimidazoles Derivatives for Anti-Inflammatory Screening



Address:   Jacob Jincy1, Dey Tathagata1*, Ghate Manjunath2 and Baby Shaji3
1East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore- 560049
2Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035
3Badar Al Samaa Hospital, P.O Box-516, P C-321, Barka, Sultanate of Oman
*Corresponding Author
DOI No:

ABSTRACT:
A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.
KEYWORDS:
Coumarino benzimidazoles, PEG5000, Anti-inflammatory activity.
Cite:
Jacob Jincy, Dey Tathagata, Ghate Manjunath, Baby Shaji. Synthesis of Some Novel Coumarino Benzimidazoles Derivatives for Anti-Inflammatory Screening. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 116-120.
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