Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   172-174

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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UV Spectrophotometric Determination of Norethisterone in Tablets



Address:   Rama Chandra Reddy A.*, Roshna K., P. Mohanraj, Kulanthavel T. M, SaravananV. S. and Ganesh V
Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode – 638112, TN
*Corresponding Author
DOI No:

ABSTRACT:
A new simple, sensitive, precise and economical spectrophotometric method of analysis for a bulk drug was developed and validated. The method employed methanol as solvent. The drug was then estimated at 270 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.999 in the concentration range 0.5-3.0 µg/ml. The mean value of correlation coefficient, slope and intercept were 0.999, 0.0332 and 0.0002 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for norethisterone was found to be 0.01987 (µg/ml) and 0.06024 (µg/ml) respectively. The method has been successfully applied in the analysis of marketed formulations.
KEYWORDS:
Norethisterone; UV spectrophotometric analysis.
Cite:
Rama Chandra Reddy A., Roshna K., P. Mohanraj, Kulanthavel T. M, SaravananV. S., Ganesh V. UV Spectrophotometric Determination of Norethisterone in Tablets. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 172-174.
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