Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   175-177

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Estimation of Rizatriptan Benzoate



Address:   Vivek Rajendra*, Amol Khedkar, Alpana Kulkarni, Mohd. Hassan G Dehghan, Maria Saifee and Swaroop Lahoti
Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad (MS)-431001
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, rapid, precise, cost effective and reproducible UV spectrophotometric method has been developed for estimation of Rizatriptan Benzoate in bulk and tablet dosage form. Rizatriptan benzoate shows maximum absorbance at 225 nm with molar absorptivity of 8.9583×10 4 l/mol.cm. Beer's law was obeyed in the concentration range of 1-10 µg/ml. Results of analysis were validated by statistical analysis and by recovery studies. The method was validated with respect to linearity, precision, LOD, LOQ, Sandell’s sensitivity and specificity. The proposed method was found to be accurate and precise for routine estimation of Rizatriptan Benzoate in bulk and tablet dosage forms.
KEYWORDS:
UV spectrophotometer, Rizatriptan Benzoate.
Cite:
Vivek Rajendra, Amol Khedkar, Alpana Kulkarni, Mohd. Hassan G Dehghan, Maria Saifee, Swaroop Lahoti. Spectrophotometric Estimation of Rizatriptan Benzoate. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 175-177.
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