Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   225-228

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms



Address:   P Nagaraju1*, Z Vishnu Vardhan2 and JVLN Seshagiri Rao3
1Hindu College of Pharmacy, Amaravathi Road, Guntur, 522002 (Andhra Pradesh)
2Department of Environmental Sciences, Acharya Nagarjuna University, Nagarjuna Nagar
3University College of Pharmaceutical Sciences, Andhra University, Vishakapatnam
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH – 6) in the ratio 60:40 delivered at a flow rate of 1ml / min and wavelength of detection at 232nm. The retention times of Atorvastatin calcium and Ezetimibe were 3.7 min and 6.1 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.
KEYWORDS:
Atorvastatin calcium, ezetimibe, RP-HPLC.
Cite:
P Nagaraju, Z Vishnu Vardhan, JVLN Seshagiri Rao. A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms. Asian J. Research Chem. 3(1):Jan.-Mar. 2010 page 225-228.
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