Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   26-28

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Estimation of Rosiglitazone in Bulk and Tablet Dosage Forms by HPTLC Method

Address:   Meeta A Jiladia*1, SS Pandya2, Ashok G Jiladia3 and Viidyasagar G1
1Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi- 370460
2Babaria Institute of Pharmacy, Vadodara - 391240
3Jiladia Hospital, New Anjar, Anjar (Kutch) - 370110
*Corresponding Author

A simple and sensitive, HPTLC method has been developed for the quantitative estimation of rosiglitazone in its single component tablet formulations (4 mg). Rosiglitazone was chromatographed on silica Gel 60 F254TLC plate using Toluene:acetone: ammonia (4.5:5.5:0.1 v/v) as mobile phase. Rosiglitazone showed Rf value 0.55±0.03 and scanned at 318 nm using Camag TLC Scanner 3. The method was validated in terms of linearity (200–2000 ng/spot), precision (intra-day variation 0.6 to 3.6%, inter-day variation 0.6 to 3.0%), accuracy (98.1 to 103.3%) and specificity. The limit of detection and limit of quantification for rosiglitazone were found to be 30 ng/spot and 100 ng/spot, respectively. The developed method was successfully used for the assay of rosiglitazone tablet formulations. The method is simple, sensitive and precise; it can be used for the routine quality control testing of marketed formulations.
Rosiglitazone, toluene, acetone, ammonia, HPTLC.
Meeta A Jiladia, SS Pandya, Ashok G Jiladia, Viidyasagar G. Estimation of Rosiglitazone in Bulk and Tablet Dosage Forms by HPTLC Method. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 26-28.
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