Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   292-295

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Analgesic Activity of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles

Address:   Rakesh Saini1*, Saurabh Chaturvedi1, AN Kesari1, Rijuved Garg2 and Amita Verma3
1Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, (U. P.), India 2Department of Pharmacy, Aligarh College of Pharmacy , Aligarh (U.P)
3 Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P)
*Corresponding Author

1, 2, 3 benzotriazole derivative also show several pharmacological activities viz.example. Antimicrobial activity, Anti inflammatory, Anti analgesic activity, Anticancer etc. On the basis of our observation the parent research work was carried out to synthesize 1, 2, 3 triazole substituted 1, 3, 4 oxadiazoles and to further evaluate Analgesic activity. Synthesis of (ethyl 2- (1H Benzo [d] [1, 2, 3] triazole –1- yl] acetate) and (2H – benzo [d] [1,2,3] triazole – 1 – yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR specteoscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on albino rats. The present investigation deals with the synthesized compounds possessing good Analgesic activity.
Hydrazine, Benztriazole, Analgesic activity.
Rakesh Saini, Saurabh Chaturvedi, AN Kesari, Rijuved Garg, Amita Verma. Synthesis and Analgesic Activity of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles. Asian J. Research Chem. 3(2): April- June 2010; Page 292-295.
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