Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   302-304

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Methods of Loratadine in Bulk and Pharmaceutical Formulation



Address:   N Harikrishnan*, Deepthi R, Manjusha V, P Satya Vani, MV Asha Jyothi, and C Roosewelt
Vels University, Dept of Pharmaceutical Analysis, P.V. Vaithiyalingam Road, Allavaram, Chennai.600 117
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of loratadine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 245nm.The percentage recovery of loratadine is 99% ranged from (99.97 ± 0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-30µg/ml having line equation y = 0.0043x + 0.01 with correlation coefficient of 0.99868. Results of the analysis were validated statistically and by recovery study.
KEYWORDS:
UV spectrophotometry, loratadine.
Cite:
N Harikrishnan, Deepthi R, Manjusha V, P Satya Vani, MV Asha Jyothi, C Roosewelt. Development and Validation of UV Spectrophotometric Methods of Loratadine in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(2): April- June 2010; Page 302-304.
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