Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   305-307

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Activity of 5-substituted and 5, 6-disubstituted-2-(N, N-Dialkyl Thiocarbamido)Benzimidazoles



Address:   YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary and AS Bobade*
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel Mumbai -12
*Corresponding Author
DOI No:

ABSTRACT:
Heterocyclic compounds such as 5-substituted and 5,6-disubstituted-2- (N, N-dialkyl Thiocarbamido) benzimidazoles were synthesized by condensation of 5-substituted and 5,6-disubstituted-2-mercapto benzimidazoles with N, N-dialkyl carbamoyl chlorides and triethyl amine in dry 1,4-dioxane. Synthesized compounds were further screened for their biological activity and found to have good to moderate antibacterial and antifungal activity. The structures of compounds have been established on basis of their elemental analysis and spectral data (IR and NMR).
KEYWORDS:
Mercapto Benzimidazole, antifungal, antibacterial, N, N-dialkyl carbamoyl chloride.
Cite:
YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary, AS Bobade. Synthesis and Biological Activity of 5-substituted and 5, 6-disubstituted-2-(N, N-Dialkyl Thiocarbamido)Benzimidazoles.Asian J. Research Chem. 3(2): April- June 2010; Page 305-307.
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