Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   308-311

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis and Screening of Biphenyl ether derivatives for their Anti-inflammatory and Analgesic activity



Address:   HG Akkamma*, BS Vikram, T Srinivas Rao and D Baggiya Selvi
Karnataka College of Pharmacy, # 33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064
*Corresponding Author
DOI No:

ABSTRACT:
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1- Ulmaan ether synthesis, Step-2- Reduction of NO2, Step-3- Condensation reaction, Step-4- Nitration and evaluated for their anti-inflammatory and analgesic activities. The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti- inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
KEYWORDS:
Biphenyl ether derivatives, phenoxy methane sulphonamide derivatives, Non-sterodial anti-inflammatory and analgesic drugs.
Cite:
HG Akkamma, BS Vikram, T Srinivas Rao, D Baggiya Selvi. Synthesis and Screening of Biphenyl ether derivatives for their Anti-inflammatory and Analgesic activity. Asian J. Research Chem. 3(2): April- June 2010; Page 308-311.
[View HTML]      [View PDF]



Visitor's No. :   120755