Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   319-323

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazoles

Address:   Prabhu C Jalihal1*, Suresh Sharabsappa2 and Basavaraj Kilarimath2
1Department of Pharmaceutical Chemistry H.S.K. College of Pharmacy Bagalkot 580071 Karnataka
2Department of Pharmaceutical Chemistry KLE’S College of Pharmacy, Vidyanagar, Hubli 580031, Karnataka
*Corresponding Author

Ortho, meta and para-nitroaniline was treated with methyl methacrylate in the presence of acetic acid to get methyl 2-methyl-3-(o, m and p-nitroanilino)propionates which was further treated with hydrazine hydrate (99 %) in the presence of absolute ethanol to get 2-methyl-3-(o, m and p-nitroanilino) propanohydrazide. The above compound was then treated with carbon disulphide in the presence of alcoholic KOH and ethanol as a solvent to get 5-{1-methyl-2-(o, m andp-nitroanilino) ethyl}-1,3,4-oxadiazole-2-thiol.These compounds were further treated with mopholine / piperidine / diethyl amine/ dimethyl amine / diphenyl amine to get title compounds. The newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.
Oxadiazole, propionates, propanohydrazide.
Prabhu C Jalihal, Suresh Sharabsappa, Basavaraj Kilarimath. Synthesis and Antimicrobial Activity of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazoles. Asian J. Research Chem. 3(2): April- June 2010; Page 319-323.
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