Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   339-341

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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UV-Spectrophotometric Estimation of Atorvastatin Calcium in Tablet Dosage Form



Address:   Pandurang N Dhabale*, Vijay Jadhav and Chandrakant Raut
Government College of Pharmacy, Karad, Dist-Satara-415124, M.S., India
*Corresponding Author
DOI No:

ABSTRACT:
A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of atorvastatin calcium in tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 247.5 nm. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer’s law in the concentration range from 3µg/ml to 30 µg/ml. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies. These methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.
KEYWORDS:
absorbance maxima, atorvastatin calcium, Derivative spectroscopy.
Cite:
Pandurang N Dhabale, Vijay Jadhav, Chandrakant Raut. UV-Spectrophotometric Estimation of Atorvastatin Calcium in Tablet Dosage Form. Asian J. Research Chem. 3(2): April- June 2010; Page 339-341.
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