Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   342-345

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs



Address:   YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary and AS Bobade*
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel Mumbai -12
*Corresponding Author
DOI No:

ABSTRACT:
A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.
KEYWORDS:
Benzimidazole, antimicrobial, phenylthiocarbamoyl derivatives, benzoyl chloride.
Cite:
YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary, AS Bobade. Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs. Asian J. Research Chem. 3(2): April- June 2010; Page 342-345.
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