Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   355-358

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some 3-Substituted -4H-1, 2, 4-Triazole Derivatives



Address:   Goyal PK1*, Bhandari A2, Rana AC3 and Bele DS4
1B N Girls’ College of Pharmacy, Udaipur (Raj)
2Jodhpur Pharmacy College, Jodhpur (Raj)
3Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh
4B N College of Pharmacy, Udaipur (Raj.)
*Corresponding Author
DOI No:

ABSTRACT:
Five new 3-substituted -4H-1, 2, 4- triazoles derivates 4 (a-e) were synthesized by treatment of 4-alkyl diazo substituted 4H-1, 2,4- triazoles- 3-thiole with different aliphatic and aromatic amines to give the titled compounds. All the synthesized derivatives were characterized by spectral (UV, IR, 1H-NMR, MS) and elemental analysis. The in vitro antimicrobial activity of all the derivatives were evaluated against the pathogens, S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Some derivatives were found to possess very promising antimicrobial activity.
KEYWORDS:
4H-1, 2, 4-triazole, antimicrobial.
Cite:
Goyal PK, Bhandari A, Rana AC, Bele DS. Synthesis and Antimicrobial Activity of Some 3-Substituted -4H-1, 2, 4-Triazole Derivatives. Asian J. Research Chem. 3(2): April- June 2010; Page 355-358.
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