Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   249-254

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Combinatorial Chemistry: A New Approch for Drug Discovery

Address:   Parimal M Prajapati*, Yatri Shah, DJ Sen and CN Patel
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author

Combinatorial chemistry is a technology for creating a multitude of different compounds by reacting different combinations of interchangeable chemical "building blocks." The compounds are then screened for their ability to carry out a specified function, most commonly to act as drugs to treat a disease. Combinatorial chemistry allows the rapid synthesis and testing of many related compounds, greatly speeding the pace of drug discovery. Combinatorial chemistry is a method for reacting a small number of chemicals to produce simultaneously a very large number of compounds, called libraries, which are screened to identify useful products such as drug candidates. combinatorial chemistry can be explained simply, its application can take a variety of forms, each requiring a complex interplay of classical organic synthesis techniques, rational drug design strategies, robotics, and scientific information management. Combinatorial technologies offer significant advances over traditional scientific research methodologies. In particular, their high-speed approach promises faster results at considerably lower costs than conventional techniques. combinatorial chemistry libraries requires an application that understands the science behind combinatorial chemistry while managing the chemical and biological data generated by combinatorial chemistry programs.
Combinatorial Chemistry: A New Approch for Drug Discovery.
Parimal M Prajapati, Yatri Shah, DJ Sen, CN Patel. Combinatorial Chemistry: A New Approch for Drug Discovery. Asian J. Research Chem. 3(2): April- June 2010; Page 249-254.
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