Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   364-366

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Telmisartan and Pioglitazone in Pharmaceutical Dosage Form by RP-HPLC Method



Address:   Kamalakannan D1*, Vijay Amirtharaj R2 and Senthilkumar N3
J.K.K.Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam, Namakkal-Dt, Tamilnadu, India-638183
*Corresponding Author
DOI No:

ABSTRACT:
A simple, precise, accurate, rapid and reproducible RP-HPLC procedure was developed for simultaneous estimation of Telmisartan and Pioglitazone in pharmaceutical dosage form at a single wavelength. The mobile phase used was a combination of acetonitrile: 0.5% triethylamine (pH 4.5 with orthophosphoric acid) (65:35). The detection of the combined dosage form was carried out at 210 nm and flow rate set 1.3 ml/mins. Linearity obtained in the concentration range of 10 to 50 µg/ml for Telmisartan and 7.5 to 37.5 µg/ml for Pioglitazone with correlation coefficient of 0.9997 and 0.9995 respectively. The result of analysis were validated statistically recovery studies confirmed by the accuracy of the proposed method.
KEYWORDS:
Simultaneous Estimation by RP-HPLC, Telmisartan, Pioglitazone.
Cite:
Kamalakannan D, Vijay Amirtharaj R, Senthilkumar N. Simultaneous Estimation of Telmisartan and Pioglitazone in Pharmaceutical Dosage Form by RP-HPLC Method. Asian J. Research Chem. 3(2): April- June 2010; Page 364-366.
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